I-OMe-Tyrphostin AG 538

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) 是 IGF-1R 激酶的特异性抑制剂。I-OMe-Tyrphostin AG 538 抑制 IGF-1R 介导的信号传导，并优先对营养缺乏的 PANC1 细胞产生细胞毒性。I-OMe-Tyrphostin AG 538 是具有 ATP 竞争性的 PI5P4Kα抑制剂，IC50 为 1 μM。

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM.

Cell Viability Assay Cell Line:PANC-1 cells Concentration:0.1, 1, 10, 1000 μM Incubation Time:24 hours Result:Cytotoxic to PANC-1 cells in nutrient-deprived medium.Western Blot Analysis Cell Line:PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration:0.03, 0.3, 3 μM Incubation Time:1 hour Result:Blocked phosphorylation of IGF-1R, Akt and Erk.

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PI3K/Akt/mTOR signaling

PI3K

PI3K | IGF-1R

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1094048-77-7

437.19

C17H12INO5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (114.37 mM; 超声助溶 )

COc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O

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(-20℃)

With Ice Pack

≥ 2 years